Studies on the Mechanism of Destruction of the Toxic Action of Wheat Gluten in Coeliac Disease by Crude Papain.
نویسندگان
چکیده
The toxic action of wheat gluten on two patients was eliminated after predigestion of gluten by crude papain. This change is thought to be due to an enzyme which liberates ammonia from gluten. It is not thought that this particular mechanism operates in the normal intestinal cell but it is envisaged that one of the peptide bonds of the coeliac active constituent (possibly a N-glutaminyl peptide) is normally split by a specific intestinal peptidase which is defective in coeliac patients.
منابع مشابه
Gluten - Not a Friendly Protein
Introduction: Gluten is a protein found in grains. Research has shown that the gluten that is in grains of wheat, barley, rye, and oats (to a lesser degree) is toxic to many individuals. While gluten is essential for the make-up of these 4 grains, our bodies do not need it. Is it healthful? The protein in today’s wheat is poorly digested and can be harmful. An estimated 95% of prepared fo...
متن کاملThe review of pathogenic mechanism of Aeromonas hydrophila and action of tetracycline against it in aquatic animals
Aeromonas hydrophila is one of common bacterial disease in aquatic animals and its outbreak cause to decrease of aquatic production. Aeromonas disease is due to a protein toxin, aerolysin that exported by Aeromonas hydrophila. This protein toxin forms channels on target cells membrane, disrupting normal activities and cause to destruction and death of them. Aerolysin toxic protein is secreted b...
متن کاملCoeliac disease and noncoeliac gluten sensitivity.
The spectrum of gluten-related disorders was restricted to coeliac disease and wheat allergy, but the new contemporary entity referred to as noncoeliac gluten sensitivity has gained recognition mainly in adults but also in children. Noncoeliac gluten sensitivity is defined as the presence of a variety of symptoms related to gluten ingestion in patients in whom coeliac disease and wheat allergy ...
متن کاملReview article: safe amounts of gluten for patients with wheat allergy or coeliac disease.
For both wheat allergy and coeliac disease the dietary avoidance of wheat and other gluten-containing cereals is the only effective treatment. Estimation of the maximum tolerated amount of gluten for susceptible individuals would support effective management of their disease. Literature was reviewed to evaluate whether an upper limit for gluten content in food, which would be safe for sufferers...
متن کاملImmunological indicators of coeliac disease activity are not altered by long-term oats challenge.
Coeliac disease is a gluten-sensitive enteropathy that develops in genetically susceptible individuals. The disease exhibits many features of an autoimmune disorder. These include the production of highly specific anti-endomysial autoantibodies directed against the enzyme tissue transglutaminase. It is well accepted that wheat-, barley- and rye-based foods should be excluded in the gluten-free ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 5 شماره
صفحات -
تاریخ انتشار 1964